Claire Redfield, is continuing to look for her brother after the Raccoon City incident and she was tipped by an unknown source about an Umbrella facility in Paris. When she tried to infiltrate the facility, she was caught, after which she was taken to the Umbrella prison in Rockfort Island. She teams up with fellow prisoner, Steve Burnside, and plans to escape while an outbreak of the t-Virus is released onto the island.
This game's events are actually a dream which Claire is having after escaping Antarctica with her brother Chris Redfield at the end of CODE: Veronica.